Clinical outcomes and outcome measurement tools reported in randomised controlled trials of treatment for snakebite envenoming: A systematic review
نویسندگان
چکیده
Background Snakebite is a priority neglected tropical disease and causes range of complications that vary depending on the snake species. Randomised clinical trials have used varied outcome measures do not allow results to be compared or combined. In accordance with Core Outcomes Measurements in Effectiveness Trials (COMET) initiative, this systematic review aims support development globally relevant core set for snakebite. Methods All randomised controlled trials, secondary analyses study protocols investigating efficacy therapeutics human snakebite envenoming were eligible inclusion. Study screening data extraction conducted duplicate by two independent reviewers. primary extracted compiled, as adverse event measures. Similar grouped into domains. The was prospectively registered PROSPERO: CRD42020196160. Results This included 43 13 protocols. A total 382 and, after duplicates merged, there 153 unique outcomes. most frequently domain (‘venom antigenaemia’) less than one third studies. outcomes classified 60 Patient-centred only three Discussion Significant heterogeneity exists trials. Consensus needed select are valid, reliable, patient-centred feasible. strongly use
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ژورنال
عنوان ژورنال: PLOS Neglected Tropical Diseases
سال: 2021
ISSN: ['1935-2735', '1935-2727']
DOI: https://doi.org/10.1371/journal.pntd.0009589